Span 60
Span 60
CAS: 1338-41-6
Molecular Formula: C24H46O6
Span 60 - Names and Identifiers
| Name | Span 60 |
| Synonyms | Span-60 SPAN 60 Span 60 FEMA 3028 SPAN(R) 60 ARLACEL 60 SPAN NO 60 Span(rg 60 SPAN(TM) 60 EMALEX SPE-100S Emulsifier S-60 Sorbitan monostearate Sorbitan Monostearate SORBITAN MONOSTEARATE [2-[(2R,3S)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] octadecanoate [2-[(2R,3S,4R)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] octadecanoate |
| CAS | 1338-41-6 |
| EINECS | 215-664-9 |
| InChI | InChI=1/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20?,21?,23-,24+/m0/s1 |
| InChIKey | HVUMOYIDDBPOLL-XGKPLOKHSA-N |
Span 60 - Physico-chemical Properties
| Molecular Formula | C24H46O6 |
| Molar Mass | 430.62 |
| Density | 1.00 |
| Melting Point | 54-57°C(lit.) |
| Boling Point | 464.84°C (rough estimate) |
| Flash Point | >230°F |
| Water Solubility | Soluble in ethanol (50 mg/ml), isopropanol, mineral oil and vegetable oil. Insoluble in water. |
| Solubility | Soluble in ethanol, carbon tetrachloride, toluene, insoluble in water, acetone and solvent oil |
| Appearance | White to Brown Wax |
| Color | Cream coloured flakes |
| Odor | Slight |
| Exposure Limit | ACGIH: TWA 10 mg/m3; TWA 3 mg/m3 |
| Merck | 14,8724 |
| BRN | 6820761 |
| pKa | 13.63[at 20 ℃] |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4593 (estimate) |
| MDL | MFCD00005366 |
| Physical and Chemical Properties | White to pale yellow powder or waxy or lump-like substance, slightly fatty. The relative density of 0.98~1.0, the melting point of 51. Can be dispersed in hot water, can be miscible with oils and general organic solvents. The HLB value was 4.7. Rat oral LD5031g/kg,Adl 0~25 mg/kg(FAO/WHO,1994). |
| Use | Widely used in food, medicine, pesticide, explosives and other industries as emulsifier, paint and pigment as dispersant |
Span 60 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | WG2933500 |
| TSCA | Yes |
| HS Code | 34021300 |
| Toxicity | LD50 orally in Rabbit: 15900 mg/kg |
Span 60 - Upstream Downstream Industry
| Raw Materials | Sorbitol Stearic acid |
Span 60 - Reference
| Reference Show more | 1. [IF=9.776] Yanjiang Shao et al."US-triggered ultra-sensitive “thrombus constructor” for precise tumor therapy."J Control Release. 2020 Feb;318:136 2. [IF=7.514] Zhaojing Jiang et al."Structuring of sunflower oil by stearic acid derivatives: Experimental and molecular modelling studies."Food Chem. 2020 Sep;324:126801 |
Span 60 - Nature
Open Data Verified Data
Brown yellow wax, insoluble in water, dispersed in hot water as emulsion. Soluble in hot oil, fatty acids and various organic solvents. Acid and alkali resistance, good chemical stability to metal ions. Compatible with non-ionic, Most anionic and cationic surfactants. With emulsification, dispersion, thickening, lubrication and rust resistance.
Last Update：2024-01-02 23:10:35
Span 60 - Preparation Method
Open Data Verified Data
Sorbitan was esterified with stearic acid.
Last Update：2022-01-01 09:28:38
Span 60 - Standard
Authoritative Data Verified Data
This product is a mixture of Sorbitan and stearic acid forming ester. The system is sorbitol dehydration, in alkaline catalysis, and hard wax acid esterification. Alternatively made by direct esterification of sorbitol with stearic acid at 180-280°C.
Last Update：2024-01-02 23:10:35
Span 60 - Trait
Authoritative Data Verified Data
- This product is a light yellow to tan waxy solid with slight odor.
- This product is very slightly soluble in ethyl acetate, insoluble in water or acetone.
acid value
The acid value of this product (General 0713) is not more than 10.
saponification value
The saponification value of this product (General 0713) is 147~157.
hydroxyl value
The Hydroxyl value of this product (General 0713) is 235~260.
iodine value
The iodine value of this product (General 0713) is not more than 10.
peroxide value
The peroxide value of this product (General 0713) is not greater than 5.
Last Update：2022-01-01 11:26:12
Span 60 - Introduction
Siban 60 is a biodegradable surfactant based on natural fatty acids (stearic acid) and sugar alcohol sorbitol. This sorbitan ester can form an efficient water/oil emulsifier, especially when used in combination with its polyethoxylated derivative, Tween 60. Chemical group: chemical group nonionic surfactant-sorbitan and ethoxylated sorbitan fatty acid composition: stearic acid (C18:0) about 50%; The others are mainly palmitic acid (C16:0). Excellent water/oil emulsifier, with strong emulsification and dispersion, wetting and other effects. It can be mixed with various types of surfactants.
Last Update：2022-10-16 17:13:27
Span 60 - Use
Open Data Verified Data
used as emulsifier and stabilizer. Mainly used in medicine, cosmetics, food, pesticides, coatings and plastics industry; Textile industry as antistatic agent, soft oil agent. For plant protein drinks, juice drinks, milk, milk sugar, ice cream, bread, cakes, solid drinks, chocolate, the maximum use of 3. Og/kgI cream, instant coffee, dry yeast, hydrogenated vegetable oil dosage 10. Og/kg.
Last Update：2022-01-01 09:28:39
Span 60 - Differential diagnosis
Authoritative Data Verified Data
take about 2g of this product, put it in a 250ml flask, add 100ml of ethanol and 3. 5g of potassium helium oxide, and mix well. Heat reflux for 2 hours, add about 100ml of water, transfer to 250ml beaker while hot, evaporate on a water bath and continue to add water, continue to evaporate until no ethanol odor, finally heat 100ml of water, slowly Dropwise add sulfuric acid solution (1-2) while hot to Neutral litmus paper, record the consumed volume, continue to Dropwise add sulfuric acid solution (1-2) (about 10% of the consumption volume) the liquid in the lower layer was clarified. The above solution was extracted with n-hexane for 3 times, each time 100ml, the n-hexane layer was discarded, the water layer solution was taken to adjust the pH value to 10% with 7.0 potassium hydroxide solution, evaporated to dryness by water bath, and the residue was added with 150ml anhydrous ethanol, stir with a glass rod, if necessary, triturate the residue, boil in a water bath for 3 minutes, place the above solution in a funnel covered with diatomite, filter, evaporate the filtrate, dissolve the residue with 2ml of methanol, as a test solution, 33mg of Isosorbide, 25mg of 1, 4-desosorbide, and 25mg of sorbitol were separately weighed, and 1 ml of methanol was added for dissolution, and used as a mixed reference solution. According to the thin layer chromatography (General 0502) test, absorb 2ul of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with acetone-glacial acetic acid (50:1) as the developing solvent, expand, take out, dry, spray with sulfuric acid ethanol solution (1-2) until it is just wet, heat until the spots are clear, immediately check, the position and color of the spots of the test solution should be the same as that of the control solution.
Last Update：2022-01-01 11:26:13
Span 60 - Safety
Open Data Verified Data
non-toxic, odorless. ADI 0~25mg/kg.
Last Update：2022-01-01 09:28:39
Span 60 - Exam
Authoritative Data Verified Data
fatty acid composition
take this product O.lg, put in a 50ml round-bottom flask, add 4ml of 0.5mol/L potassium hydroxide methanol solution, heat and reflux in a 65°C water bath for 10 minutes, let it cool, add 5ml of 14% boron trifluoride methanol solution, heat and reflux in a 651 water bath for 2 minutes, cool down, add 5ml of n-hexane, continue heating and reflux in a 65°C water bath for 1 minute, cool down, add 10ml of saturated gasification sodium solution, and shake well, the mixture was allowed to stand to separate into layers, and the upper layer was taken and dried over anhydrous sodium sulfate. Test according to Gas chromatography (General 0521). Wool with polyethylene glycol as fixative solution
The thin column is a chromatographic column, the initial temperature is 150°C, the temperature is maintained for 3 minutes, the temperature is raised to 220°C at a rate of 5°C per minute, and the temperature is maintained for 10 minutes; The inlet temperature is 240°C, and the detector temperature is 280°C. Take appropriate amount of methyl palmitate and methyl stearate respectively, add n-hexane to dissolve and dilute the solution containing 1 mg per 1 ml, inject 1M1 into gas chromatograph, record chromatogram, the number of theoretical plates shall not be less than 20000 based on the peak of methyl stearate, and the resolution of each chromatographic peak shall meet the requirements. The upper liquid lul is injected into the gas chromatograph, the chromatogram is recorded, and the peak area is calculated according to the area normalization method. This product contains not less than 40.0% of stearic acid and not less than 90.0% of the sum of palmitic acid and stearic acid.
moisture
take this product, with anhydrous methanol-dichloromethane (1 : 1) as the solvent, according to the moisture determination method (General 0832 first method 1 ), determination, containing water not more than 1.5%.
ignition residue
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:26:14
Span 60 - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and Defoamers.
Last Update：2022-01-01 11:26:14
Span 60 - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 11:26:14
Span 60 - Reference Information
| FEMA | 3028 | SORBITAN MONOSTEARATE |
| hydrophilic and hydrophilic balance value (HLB value) | 4.7 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | span 60 is mainly used in medicine, cosmetics, food, pesticides, coatings, textiles, plastics as emulsifiers, stabilizers, textile industry as antistatic agents, softeners, etc. as W/O food emulsifier, used alone or mixed with Tween 60, Tween 80 and Tween 65. China stipulates that it can be used for instant coffee, dry yeast, cream and hydrogenated vegetable oil, with a maximum usage of 10.0 g/kg. The maximum usage in vegetable protein, juice beverage, solid beverage, ice cream, milk, candy, chocolate, bread and cakes is 3.0 g/kg. widely used as emulsifier in food, medicine, pesticide, explosive and other industries, as dispersant in paint and pigment used as gas chromatography stationary liquid, emulsifier, thickener this product is used as emulsifier, stabilizer in medicine, cosmetics, food, pesticide, coating, plastic industry, as antistatic agent and soft oilagent in textile industry. this product is an excellent water/oil emulsifier with strong emulsifying effect, dispersion, wetting and other effects. It can be mixed with various types of surfactants. It is mainly used as an antistatic agent and a soft oilizing agent for acrylic fibers, and can also be used as an emulsifier for food, medicine, pesticides, coatings, plastics and cosmetics. Siban 60 is an excellent water/oil emulsifier with strong emulsifying effect, dispersion, wetting and other effects. It can be mixed with various types of surfactants. It is mainly used as an antistatic agent and a soft oilizing agent for acrylic fibers, and can also be used as an emulsifier for food, medicine, pesticides, coatings, plastics and cosmetics. |
| content analysis | determined by the method in "sorbitan monolaurate (10042)" (according to FCC regulations, polyol content is 29.5% ~ 33.5%, fatty acid content is 71~75g). |
| toxicity | ADI 0~25 mg/kg(FACI/WHO,2001). Can be safely used in food (FDA, 172.842,2000). LD50,31g/kg (rat, oral). |
| usage limit | GB 2760-2001(g/kg): vegetable protein drinks, juice drinks, milk, candy, ice cream, bread, cakes, solid drinks, chocolate, 3.0; Cream, instant coffee, dry yeast, hydrogenated vegetable oil, 10.0. FAO/WHO(1984): margarine, chocolate and sandwich chocolate 10 g/kg (total emulsifier 15 g/kg). FDA, 172.842(2000): Edible oil rubbing top material and oil-water emulsification 0.4%; 0.61% of cake and premixed powder (dry basis); Candy coating l%; Cake coating 0.7%; Rehydration of active dry yeast l%. |
| production method | is obtained by esterification with stearic acid after sorbitol loses water and becomes a ring. 700 kg sorbitol (50% content) is added into the reaction kettle, dehydrated under reduced pressure to turn up small bubbles in the kettle. Then 780 kg of molten stearic acid and 2.5kg of 50% lye are added. Under reduced pressure, the temperature is raised to 170 ℃ within 2 h, then the temperature is slowly raised to 180~190 ℃. After keeping the temperature for 2 h, the temperature is continued until keeping the temperature at 210 ℃ for 4 h. The acid value is measured by sampling, and when the acid value reaches about 8, the esterification reaction ends. Let stand, cool overnight, after removing the bottom coking substance, add an appropriate amount of hydrogen peroxide to decolorize, finally raise the temperature to about 110 ℃, hot press form, cool and package to obtain the finished product. by one-step method, equimolar fatty acid, sorbitol and appropriate amount of catalyst sodium hydroxide are added to the reaction kettle, and under the protection of nitrogen flow, dehydration and esterification reaction are started when heated to 190 ℃. When heating to 230~250 ℃ is continued, esterification is carried out while intramolecular dehydration is carried out to anhydride, and the reaction time is about 5~7h. After the reaction, it is cooled to 85~95 ℃, add appropriate amount of hydrogen peroxide to decolorise for 30min to obtain the product. First anhydride and then esterification Put 320kg of 50% sorbitol in a dehydration pot, add an appropriate amount of phosphoric acid, and dehydrate under reduced pressure (5332.9Pa) at 100~150 ℃ to produce sorbitol anhydride; In addition, put 290kg of stearic acid into the esterification pot, heat and melt, stir, add sorbitol anhydride and an appropriate amount of 50% sodium hydroxide solution, react at 170~210 ℃ for about 4 hours, and end the reaction when the acid value of the reaction solution is less than 5; cool to 110 ℃, add 2kg of 30% hydrogen peroxide to decolorize (Te can be decolorized with activated carbon), finally release the material in a cooling plate while hot, and crush to obtain about 395kg of powdered product. First esterification and anhydride at 200~260 ℃ equimolar stearic acid, sorbitol and an appropriate amount of alkaline catalyst sodium hydroxide esterification reaction, when the acid value is less than 10, add acid catalyst phosphoric acid, and then at 180~240 ℃ dehydration into anhydride is the product. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:01:54
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View History
Span 60
2-Methoxynicotinaldehyde
2-苯基-3-羟基丙酸
(S)-4-ISOPROPYL-3-PROPIONYL-1,3-OXAZOLIDINE-2-THIONE
ETHYL 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE
phosphomycin disodium salt
DL-邻氯-A-氨基苯乙酸
油醇聚醚-10 磷酸酯
CHLOROETHANE
N-(正丁基磺酰基)-O-[4-(4-哌啶基)丁基]-L-酪氨酸盐酸盐
2-Methoxynicotinaldehyde
2-苯基-3-羟基丙酸
(S)-4-ISOPROPYL-3-PROPIONYL-1,3-OXAZOLIDINE-2-THIONE
ETHYL 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE
phosphomycin disodium salt
DL-邻氯-A-氨基苯乙酸
油醇聚醚-10 磷酸酯
CHLOROETHANE
N-(正丁基磺酰基)-O-[4-(4-哌啶基)丁基]-L-酪氨酸盐酸盐
Raw Materials for Span 60